Etanercept is a fully human, soluble TNF- receptor dimeric fusion protein produced by recombinant technology using Chinese hamster ovary cells. It consists of two molecules of the p75 TNF-a receptor linked to the constant Fc portion of IgG1.The dimeric structure of etanercept permits the molecule to bind to two molecules of TNF-a, either free or membrane bound, simultaneously, and thereby neutralizing TNF-a's proin-flammatory actions. The dimeric structure of etaner-cept also causes it to have a 50- to 1,000-fold higher affinity for TNF- than the naturally occurring monomeric soluble form of the receptor.
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