Pharmacokinetics in Pediatric Crohns Patients

In pediatric Crohn's patients (mean age 10.5 ± 3.3 years), the levels of serum infliximab were determined after infusions of 5 mg/kg at week 2 and at week 6, 4 weeks after the second infusion. The trough infliximab concentration was 16.7 + 7.3 ^g/ml at week 2 and

1000,

100h

Infusion

100h

Infusion

-•- 5 mg/kg Infliximab (n = 28) -■- 10 mg/kg Infliximab (n = 30)

Fig. 2.2. Profile of serum infliximab concentrations vs time for fistula patients who received three infusions of 5 or 10 mg/kg infliximab at weeks 0, 2 and 6 (arrows). Serum samples were obtained before and after each infusion and at the indicated time points after the third infusion. Each point represents the median result for that time period and dose group

-O- 5 mg/kg Infliximab -Q- 10 mg/kg Infliximab

Infusion

-•- 5 mg/kg Infliximab (n = 28) -■- 10 mg/kg Infliximab (n = 30)

Fig. 2.2. Profile of serum infliximab concentrations vs time for fistula patients who received three infusions of 5 or 10 mg/kg infliximab at weeks 0, 2 and 6 (arrows). Serum samples were obtained before and after each infusion and at the indicated time points after the third infusion. Each point represents the median result for that time period and dose group

-O- 5 mg/kg Infliximab -Q- 10 mg/kg Infliximab

Fig. 2.3. The median half-life of infliximab was determined as 7.62 days (interquartile range 6.62-10.15 days) for the 5-mg/ kg dose group and 9.97 (interquartile range 6.17-10.14) days for the 10-mg/kg dose group (Gottlieb et al. 2003)

8.8 ±7.1 ^g/ml at week 6. This translates into a terminal half-life of 9.5 days and a mean residence time of 13 days. No infliximab (detection limit 1.8 ^g/ml) was detected in serum of children at week 8 after sequential treatment with 5-mg/kg doses (Candon et al. 2006).

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