Hematologic Complications

Platelet counts at or below 52,000 cells/^l were observed in eight subjects during clinical trials. Seven (one patient was lost to follow-up) were treated with systemic corticosteroids, with resolution. Post-marketing surveillance has reported cases of severe thrombo-cytopenia as well, and physicians should monitor plate let count closely. Patients experiencing thrombocyto-penia while taking efalizumab should discontinue treatment (Raptiva package insert, 2005). Hemolytic anemia, usually 4-6 months after the initiation of therapy, was noted, and treatment with efalizumab should be stopped if this develops.

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