Genetic Epidemiology

The relative risk for PsA amongst first degree relatives is second only to ankylosing spondylitis amongst rheumatic diseases; thus the genetic association for PsA is strong (Moll and Wright 1973; Rahman and Elder 2005). Current research evidence points to a multifactorial pattern of inheritance (Rahman and Elder 2005) with a possible parent-of-origin effect (paternal) (Rahman et al. 1999). The concordance of PsA in identical twins is 30-40 % (Sege-Peterson and Winchester 1999).

PsA is associated with human leukocyte antigen (HLA) class 1 alleles. Linkage with the short arm of chromosome 6 has been shown, demonstrating associations with HLA-B13, B-17, B-27, B-38, B-39, HLA-Cw6, and HLA-DRB1*07 (Gladman et al. 1986, 2003). Further research into regions outside the MHC region is underway.

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