The relative risk for PsA amongst first degree relatives is second only to ankylosing spondylitis amongst rheumatic diseases; thus the genetic association for PsA is strong (Moll and Wright 1973; Rahman and Elder 2005). Current research evidence points to a multifactorial pattern of inheritance (Rahman and Elder 2005) with a possible parent-of-origin effect (paternal) (Rahman et al. 1999). The concordance of PsA in identical twins is 30-40 % (Sege-Peterson and Winchester 1999).
PsA is associated with human leukocyte antigen (HLA) class 1 alleles. Linkage with the short arm of chromosome 6 has been shown, demonstrating associations with HLA-B13, B-17, B-27, B-38, B-39, HLA-Cw6, and HLA-DRB1*07 (Gladman et al. 1986, 2003). Further research into regions outside the MHC region is underway.
Was this article helpful?
Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.