Butler M (2005) Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals. Appl Microbiol Biotechnol 68:283-291 CamPath® (alemtuzumab) (2005) Full prescribing information. Genzyme, Cambridge, MA Casadevall N, Rossert J (2005) Importance of biologic follow-ons: experience with EPO. Best Pract Res Clin Haematol 18:381-387
Chu L, Robinson DK (2001) Industrial choices for protein production by large-scale cell culture. Curr Opin Biotechnol 12:180-187
Enbrel® (etanercept) (2005) Full prescribing information. Immunex Corporation, marketed by Amgen and Wyeth Pharmaceuticals, Thousand Oaks, CA Epogen® (epoetin alfa) (2005) Full prescribing information.
Amgen, Thousand Oaks, CA F-D-C Reports (2005) FDA clears 31 new molecular entities in 2004, up 10 from previous year. Pharmaceuticals Approvals Monthly 10 (January 15):3-5 Gerngross TU (2004) Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nat Biotechnol 22:1409-1414 Griffiths B (2001) Scale-up of suspension and anchorage-
dependent animal cells. Mol Biotechnol 17:225-238 Herceptin® (trastuzumab) (2005) Full prescribing information. Genentech, South San Francisco, CA Hu WS, Aunins JG (1997) Large-scale mammalian cell culture.
Curr Opin Biotechnol 8:148-153 Humira® (adalimumab) (2005) Full prescribing information. Abbott Laboratories, North Chicago, IL
Jenkins N, Curling EM (1994) Glycosylation of recombinant proteins: problems and prospects. Enzyme Microb Technol 16:354-364
Jenkins N, Parekh RB, James DC (1996) Getting the glycosyla-tion right: implications for the biotechnology industry. Nat Biotechnol 14:975-981 Johnson IS (1983) Human insulin from recombinant DNA
technology. Science 219:632-637 Lawrence S (2005) Biotech drug market steadily expands. Nat
Biotechnol 23:1466 Lubiniecki AS, Lupker JH (1994) Purified protein products of rDNA technology expressed in animal cell culture. Biologi-cals 22:161-169 Mylotarg® (gemtuzumab ozogamicin) (2006) Full Prescribing
Information. Wyeth Pharmaceuticals, Philadelphia, PA Remicade® (infliximab) (2005) Full prescribing information.
Centocor, Inc., Malvern, PA Simson H (2002) Growth hormone replacement therapy for adults: into the new millennium. Growth Hormone IGF Res 12:1-33
Synagis® (palivizumab) (2004) Full prescribing information.
MedImmune, Inc., Gathersburg, MD Thiel KA (2004) Biomanufacturing, from bust to boom...to bubble? Nat Biotechnol 22:1365 -1372 Walsh G (2003a) Biopharmaceutical benchmarks - 2003. Nat
Biotechnol 21:865-870 Walsh G (ed) (2003b) Biopharmaceuticals: Biochemistry and biotechnology, 2nd edn. John Wiley & Sons, Chichester Walsh G (2005) Current status of biopharmaceuticals: approved product and trends in approvals. In: Knablein J (ed) Modern biopharmaceuticals. John Wiley & Sons, Chichester, pp 1-34 Winder R (2005) Biomanufacturing. Cell culture changes gear.
Chemistry Industry 20:18-20 Wurm FM (2004) Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol 22:1393-1398
Xolair® (omalizumab) (2005) Full prescribing information. Genentech, South San Francisco, CA
Disease-Specific Applications and Clinical Trials II
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