Distribution

Steady-state serum concentrations of efalizumab were achieved after four doses of weekly efalizumab, 1 mg/ kg, and after 8 weeks in patients receiving 2 mg/kg. At this dose level (with an initial dose of 0.7 mg/kg in the first week), the mean efalizumab plasma trough values were 9.1 ±6.7 |g/ml in the 1 mg/kg group and 23.5 ± 12.2 |g/ml in the 2 mg/kg group. Volumes of distribution of the central compartment after single intravenous doses were 110 ml/kg at dose 0.03 mg/kg and 58 ml/kg at dose 10 mg/kg.

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