Interleukin-12 and IL-23 are two related cytokines sharing a common p40 subunit that appear to be crucial in the early phase of the inflammatory reaction driving CD. p40 messenger RNA is upregulated in monocytes, macrophages, and dendritic cells in response to infection or other activating agents. These cytokines create a positive feedback loop of cross talk between T cells and macrophages that involves IFN-y and leads to the secretion of TNF by both cell types (Van Assche et al. 2005). Elevated levels of IL-23 transcripts were detected in colonic mucosa from CD patients and showed a correlation with the severity of the endoscopic lesions (Schmidt et al. 2005). Two agents under investigation, ABT-874 and CNTO 1275, both have high affinity for IL-12p40 and potently inhibit IL-12 and Il-23 biologic activity.
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.