ABT-874 is a fully human IgG1, antibody isolated from a human antibody phage display library and optimized in a collaboration between Abbott Laboratories and Cambridge Antibody Technology Inc. Results of a phase 2 placebo-controlled, double-blind study in 79 patients with CD have been published (Mannon et al. 2004). In cohort 1, patients received ABT-874 1 mg/kg or 3 mg/kg or placebo subcutaneously. One injection was followed 4 weeks later by one injection per week for 6 weeks. In cohort 2, patients received ABT-874 1 mg/ kg or 3 mg/kg versus placebo subcutaneously weekly for 7 weeks. The primary end point was safety; secondary endpoints included clinical response (CDAI reduction > 100) and remission (CDAI <150). Patients were followed for 18 weeks. Patients receiving ABT-874 in cohort 1 did not have a significantly different response versus placebo. In cohort 2, patients receiving ABT-874 at a dose of 3 mg/kg after 7 weeks of uninterrupted therapy (end of dosing) achieved greater response rates than placebo (75% vs. 25%; p = 0.03). As expected, response diminished over time after the completion of dosing at 7 weeks, and the difference between the groups was no longer significant at the end of 18 weeks (69% vs. 25%; p = 0.08). Remission rates did not differ at the end of dosing or at the end of the 18-week observation period. Patients with mucosal biopsies showed a post-treatment improvement of mucosal histologic score. Additionally, these patients had decreased secretion of IFN-y, TNF, IL-6, and IL-17bystimulated T cells and decreased secretion of IL-12 and IL-23 by stimulated antigen-presenting cells, which were associated with clinical improvement in patients treated with ABT-874. With the exception of a higher rate of local reactions at the injection site among ABT-874 patients, adverse events were similar among the groups.

Was this article helpful?

0 0
Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

Get My Free Ebook

Post a comment