Oh 107

Scheme 11 Kinoshita's first synthesis of 3.1.2

Synthetic Studies in the 1980s

Nakata-Oishi's group reported the synthesis of the dilactone intermediates (+)-105 and (±)-109 (Scheme 12) [102]. The key steps of Wasserman and Bambale's formal synthesis were alkylation of oxazole 112 and photooxy-genation of the oxazole moiety of 115 [103]. Mulzer et al. [104] prepared all possible stereoisomers of blastimycinolactol 108 by using highly selective Nozaki-Hiyama-Kishi reaction [105]. Many of the synthetic studies of 108 and 109 reported to date are omitted in this review.

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