zolines such as spiroquinazoline [93], alantrypinone (24) [94], and ser-antrypinone (25) [95] are also included. N-Acetylardeemin [96] having the pyrazinoquinazoline substructure is known as one of the most potent MDR inhibitor [97,98]. Like this example, these alkaloids often exhibit very interesting biological properties (see Sect. 1) and have drawn considerable interest of synthetic chemists. Recently comprehensive review on the chemistry of pyrazino[2,1-fr]quinazoline-3,6-dione by Avendano and Menendez has appeared [20], and in this section, some of selected examples are discussed.

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