Solid-Phase Synthesis of Quinazoline Compounds

The use of polymer-supported reagents in organic synthesis effectively reduces workup and purification to a simple filtration. Polymer-supported reagents can also be used in conjunction with the microwave heating, that has become an increasingly popular tool for combinatorial synthesis as well as green chemical synthesis in recent years [153,166-168]. Solid-phase heterocyclic chemistry has been reviewed recently by Krchnak and Holladay [168]. Application of this methodology for synthesis of quinazoline compounds is increasing rapidly, however, only a few examples are discussed in this section (see also Sect. 3.4.2).

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