Scheme 18 Synthesis of rutaecarpine and tryptanthrin [222] 3.3

Quinazolinobenzodiazepine Alkaloids

A series of quinazoline alkaloids fused with 1,4-benzodiazepinone are isolated from different fungal species or their cultures. These alkaloids including benzolmalvine A (18) [80,81], sclerotigenin (19) [82], circumdatin F [83-85], asperlicin (20) [76-79] and their analogues consist of two anthranilic acid and an amino acid forming a novel quinazolino [1,7]benzodiazepine ring systems. They show interesting biological effects [76-85] and their total syntheses have been studied actively by several groups. Selected examples will be discussed below.

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