Glutarimide Antibiotics, the Cycloheximide Family

Cycloheximide (CHX, naramycin A, actidione; 1) is one of the most famous antibiotics because of its unique, strong and broad antimicrobial spectra, and has been used as a protein synthesis inhibitor or a fungicide [1-4]. To date, a number of related compounds having a ^-substituted glutarimide moiety have been isolated [4]. In this chapter, recent works on synthesis of the glu-tarimides are reviewed.

Cycloheximide and Derivatives

A variety of cycloheximide derivatives with a modified cyclohexanone ring, an aromatic ring, an aliphatic chain, or a lactam ring, have been synthesized.

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