Caveolin1 Expression in Colon Cancer Human Colon Cancer Cell Lines

The aforementioned controversy concerning caveolin-1 expression is further highlighted by the situation in cell lines (see Table 2.2). For a number of colon adenocarcinoma cells (HT29, DLD-1, Lovo, Co112, SW480, SW620), low caveolin-1 expression levels have been reported 11, 15, 107 , while for others (T84, HCT116) caveolin-1 levels are readily detectable 5, 23, 36, 107 . A number of possible Table 2.1 Expression of caveolin-1 and caveolin-2 in intestinal tissues Table 2.1 Expression of...

Canonical Wnt Signaling in Colorectal Cancer The Role of pCatenin

Colorectal cancer is one of the most common cancers and a leading cause of cancer death worldwide. By the age of 70, roughly 50 of the Western population develops polyps, some of which will progress to cancer. The lifetime risk of developing cancer in this population is estimated to be 5 65 . Despite the fact that the incidence of this cancer has decreased in recent years as a result of the introduction of preventive measures, including the use of nonsteroidal anti-inflammatory drugs (NSAIDs)...

Role of Caveolin1 as Tumor Suppressor in Colorectal Cancer Inhibition of bCatenin TcfLef Dependent Gene Expression

Over the previous 15 years, a large amount of data has become available associating the presence of caveolin-1 with tumor suppression. However, as will be discussed later on, the ability of caveolin-1 to act in this fashion depends on the cellular context. Thus, caveolin-1 can be considered a conditional tumor suppressor. In the following paragraphs, data favoring a role for caveolin-1 as a tumor suppressor will be briefly summarized before focusing the discussion particularly on linking this...