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The selectivity between pyrimidine 26 and nitropyridone 28 is varied with structural difference of ketones 22. In a series of reactions using cyclic ketones, cycloheptanone 22n is found to show unique reactivity 44 . While cyclic ketones having a five-, six- or eight-membered ring afford corresponding bicyclic pyrimidines 26e, 26d and 26o, bicyclic pyridone 28n is predominantly produced in the case of 22n (Table 4). Although it has not been clarified why this different reactivity is observed,...

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A Stereoisomers, see Fig. 2 b Glc glucose Rha rhamnose strated by a spectrophotometric method 96 . Heart microsomes were used in the study of antioxidant and metal chelating properties of a large group of flavonoids 97 . The catechol structure in ring B and the presence of the 2,3-double bond and 3-OH group were the structural features identified to be important for antioxidant activity. Additionally, it was stressed that the 3-OH group might constitute a chelation site for Fe2+ ions. Foti et...

Author Index Volumes

The volume numbers are printed in italics Almqvist F, see Pemberton N (2006) 1 1-30 Appukkuttan P, see Kaval N (2006) 1 267-304 Ariga M, see Nishiwaki N (2007) 8 43-72 Arya DP (2006) Diazo and Diazonium DNA Cleavage Agents Studies on Model Systems and Natural Product Mechanisms of Action. 2 129-152 El Ashry ESH, El Kilany Y, Nahas NM (2007) Manipulation of Carbohydrate Carbon Atoms for the Synthesis of Heterocycles. 7 1-30 El Ashry ESH, see El Nemr A (2007) 7 249-285 Bagley MC, Lubinu MC (2006)...

Nh

Fig. 5 Structures of selected drugs and chemicals appearing in this review two leukemic resistant cell lines L121C and L5178 and in human adenocarcinoma cell line KB-V-1 169 . Barbieri et al. 170 demonstrated that quinolizidinyl derivatives of phenothiazine increased doxorubicin (77) cytotoxicity in resistant ovarian cancer cells (A2780-DX3). The presence of the rigid quinolizidine ring in the structure of the studied compounds seemed to be favorable for their anti-MDR activity. Recent studies...