Although intrauterine infection is rare, chorioamnionitis may lead to preterm labor, congenital and neonatal infections, Candida sepsis, and endometritis. In intrauterine infection, gross examination of the placenta and umbilical cord will reveal a yellow exudate on the placental surface and areas of necrosis and discrete, yellow macular lesions along the cord near the funicular vessels. Histological examination of the cord and placenta may reveal spores and pseudohyphae on periodic acid-Schiff stain, Gomori methenamine silver stains, toluidine blue, or Gram stain. There is an inflammatory infiltrate of neutrophils, lymphocytes, and histiocytes as well as microabscess formation.
Was this article helpful?