Application Of Mri To Study Metabolic Disorders

MRI is based on the principles of nuclear magnetic resonance, a spectroscopic technique used by scientists to obtain microscopic chemical and physical information about molecules (1). MRI became widely available in the mid 1980s and has become the preferred imaging modality for clinical and research anatomical imaging (2). Unlike computed tomography (CT) scanning, MRI can be obtained in multiple planes and can produce highly resolute images. By using different pulse sequences for image...

Summary

At present, conventional magnetic resonance imaging (MRI) shows no convincing structural changes in Parkinson's disease (PD) itself, but it may be useful in helping to distinguish PD from other neurodegenerative parkinsonian syndromes. Magnetic resonance spectroscopy (MRS) also may provide useful information in distinguishing PD from disorders such as multiple system atrophy. The general field of MRI and MRS is evolving rapidly, and a number of new developments may provide relevant information....

Lysosomal Disorders

Lysosomal disorders may present as a classic leukodystro-phy or a leukoencephalopathy associated with systemic manifestations. The disorders discussed are not exhaustive of lysosomal disease with white matter disorders and are meant to be representative. Metachromatic leukodystrophy is also known as MLD metachromatic leukoencephalopathy cerebral sclerosis, diffuse, metachromatic form sulfatide lipidosis arylsulfatase A deficiency arylsulfatase A (ARSA) deficiency and cerebro-side sulfatase...