Mechanisms of Action of High Doses of Dietary Antioxidants on Tumor Cells

To study the mechanisms of differential effects of antioxidant nutrients in cancer cells, it is important to establish whether the greater sensitivity of cancer cells to dietary antioxidant micronutrients (vitamin A, vitamin C, vitamin E, and carotenoids) is due to increased accumulation of antioxidants in these cells in comparison to that found in normal cells or whether cancer cells and normal cells accumulate the same levels of these antioxidant mi-cronutrients, with cancer cells being more sensitive to these micronutrients than normal cells.

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