In contrast to the effect of high doses of dietary antioxidant micronutrients, low doses of these mi-cronutrients can have no effect on the growth of cancer cells and normal cells, or they can stimulate the growth of some cancer cells without affecting the growth of normal cells. For example, vitamin C at a low dose stimulated the growth of human parotid carcinoma cells in culture (16) and human leukemic cells in culture (15), but had no effect on the growth of human melanoma cells in culture (16) or murine neuroblastoma cells (20). Polar car-otenoids at low doses can stimulate the growth of human melanoma cells in culture (17). In addition, certain amounts of antioxidants are needed for the growth of normal and cancer cells. Therefore, we do not recommend low doses of individual or multiple antioxidants during radiation therapy.
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