A randomized placebo-controlled trial on the use of antioxidants during radiation therapy has not been performed as yet. Dr. Jae Ho Kim of the Henry Ford Hospital in Detroit, Michigan, has completed a randomized pilot trial with high-dose multiple micronutrients including dietary antioxidants (vitamin C and vitamin E, and natural p-carotene) in cancer patients receiving chemotherapy and radiation therapy. Results showed that all patients tolerated high-dose micronutrients well and that quality of life was improved during radiation therapy with no adverse effect on the efficacy of standard therapy (personal communication). A few oncologists have used high dose multiple antioxi-dants in combination with standard cancer therapy, and improved outcomes have been reported (39, 40). A preliminary randomized trial with high dose antioxidants in combination with chemo-therapeutic agents (cisplatin and paclitaxel combination) in patients with advanced non-small cell lung carcinoma reported beneficial effects on tumor response and tolerance to chemotherapeutic agents for a follow-up period of one year (Table 11.6).
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