New bronchodilators

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Bronchodilators are the mainstay of current management of COPD, and the major recent advances have been in the development of long-acting bron-chodilators. Tiotropium bromide is a very promising new anticholinergic drug that has a very long duration of action. It has a high affinity and dissociates very slowly from M1 and M3-muscarinic receptors in the human lung, and it produces long-term blockade of cholinergic neural bronchoconstriction in human airway smooth muscle. However, its effects on acetylcholine release are short-lived, confirming functional selectivity for M3-receptors compared to M2-receptors. In studies of patients with COPD, tiotropium bromide gives prolonged bronchodilatation, lasting over 24h [20,21]. This suggests that tiotropium bromide will be suitable for once-daily dosing, and it is now in advanced clinical trials as a once-daily dry powder inhalation.

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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