Mcp1

Chemokines (IL-8) Mediators (LTB4)

Neutrophil

Neutrophil elastase Cathepsins

Matrix metalloproteinases

Neutrophil inhibitors

PDE4 inhibitors

Protease inhibitors

NE, MMP inhibitors a1-AT, SLPI

Alveolar repair

Emphysema

Mucus hypersecretion

Fig. 11.3 Novel targets for chronic obstructive pulmonary disease (COPD) therapy.

CD8+ lymphocyte

Neutrophil inhibitors

PDE4 inhibitors

Protease inhibitors

NE, MMP inhibitors a1-AT, SLPI

Alveolar repair

Stopping smoking

Bupropion

Alveolar macrophage

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