Micronutrients Alcohol

Nutrient

Suggested daily dose

Comment

Antioxidant supplement (containing vitamins A, C, E, and zinc and selenium) GLA

Carnitine Niacinamide Vitamin B complex

Magnesium

Zinc

(See pp. 115 for antioxidant nutrients and suggested doses)

As 1-2 g evening primrose oil

Complete formula containing at least 25 mg vitamins B1, B2, B3, and B6, 0.4-0.8 mg folic acid, and 25 |ig vitamin B12

400 mg 30-45 mg

Alcohol can cause widespread cell damage and fat peroxidation in the liver.8 Supplements may help protect against oxidative damage. Vitamin C may help detoxify alcohol9

May help reduce damage to the liver and lessen symptoms related to alcohol withdrawal in heavy drinkers12

May help reduce hepatic damage and development of fatty liver13

May help reduce damage to hepatic protein metabolism14

B vitamins are poorly absorbed and their activation is impaired by alcohol. Most heavy drinkers are deficient in many B vitamins

Deficiency is very common in heavy drinkers and can produce heart and neuromuscular problems The main enzymes that detoxify alcohol are dependent on zinc, thus zinc deficiency impairs abilityto breakdown alcohol, increasing potential harm4

Albumin

Fibrinogen

Fig. 5.37: Counteracting the toxic effects of etha-nol with nicotinamide. In a controlled trial 15 healthy males were fed a test meal accompanied by either water, 750 ml wine (12% ethanol), or 750 ml wine plus 1.25 g nicotinamide. Overthe 8-hour postprandial period, alcohol-induced impairment of hepatic protein synthesis was measured by determination of plasma albumin and fibrinogen. Nicotinamide treatment prevented the alcohol-induced fall in hepatic albumin and fibrinogen synthesis, suggesting that nicotinamide may help counteract the acute he-patotoxic effects of ethanol. (From Volpi E, et al. J Nutr. 1997;127:2199)

Albumin

Fibrinogen

Fig. 5.37: Counteracting the toxic effects of etha-nol with nicotinamide. In a controlled trial 15 healthy males were fed a test meal accompanied by either water, 750 ml wine (12% ethanol), or 750 ml wine plus 1.25 g nicotinamide. Overthe 8-hour postprandial period, alcohol-induced impairment of hepatic protein synthesis was measured by determination of plasma albumin and fibrinogen. Nicotinamide treatment prevented the alcohol-induced fall in hepatic albumin and fibrinogen synthesis, suggesting that nicotinamide may help counteract the acute he-patotoxic effects of ethanol. (From Volpi E, et al. J Nutr. 1997;127:2199)

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