Plaque rupture with severe preexisting stenosis precipitating coronary thrombosis

Br Heart J 1983 50 127-134 Abstract Ruptured atheromatous plaques were identified by step-sectioning technique as responsible for 40 of 51 recent coronary artery thrombi and 63 larger intimal haemorrhages. The degree of preexisting luminal narrowing at the site of rupture was decisive for whether plaque rupture caused occlusive thrombosis or just intimal haemorrhage. If the pre-existing stenosis was greater than 90 (histologically determined) then plaque rupture nearly always caused occlusive...

A receptormediated pathway for cholesterol homoeostasis

Animal models of hypercholesterolaemia, as described in the preceding papers, as well as humans with familial hypercholesterolemia indicated an enormous potential for the role of cholesterol metabolism in atherosclerosis. Brown and Goldstein embarked on their studies of cholesterol homoeostasis in 1972, in an attempt to understand the human genetic disease, familial hypercholesterolaemia (FH), a disease characterized by marked hypercholesterolaemia with premature myocardial infarction. FH...

Widimsky P Budesinsky T Vorac D et al Prague Study Group Investigators Reference

Eur Heart J 2003 24 94-104 Abstract BACKGROUND Primary percutaneous coronary intervention PCI is shown to be the most effective reperfusion strategy in acute myocardial infarction AMI . The aim of this multicentre national randomized mortality trial was to test whether the nationwide change in treatment guidelines transportation of all patients to PCI centres was warranted. METHODS The PRAGUE-2 study randomized 850 patients with acute ST elevation myocardial infarction presenting within lt 12 h...

Adams MR Orford JL Gavin JB Wainstein MV et al Reference

Clin Cardiol 2002 25 280-286 Abstract BACKGROUND Despite decreasing rates of acute and subacute complications of percutaneous coronary intervention PCI , these procedures are generally only performed in centers where it is possible for failed PCI to be treated by rescue coronary artery bypass graft CABG . Case reports and case series have documented successful PCI following failed CABG. We sought to confirm this decrease in the need for rescue CABG following failed PCI and to examine trends in...

Final results of the balloon vs optimal atherectomy trial BOAT

Baim DS, Cutlip DE, Sharma SK, et al. Reference Circulation 1998 97 322-331 Abstract BACKGROUND Previous directional coronary atherectomy DCA trials have shown no significant reduction in angiographic restenosis, more in-hospital complications, and higher 1-year mortality than conventional balloon angioplasty percutaneous transluminal coronary angio-plasty PTCA . DCA, however, has subsequently evolved toward a more optimal technique larger devices, more extensive tissue removal, and routine...