Twt

BCR signaling

Enhancement of BCR signaling

TLR signaling t

Proliferation and differentiation

Proliferation and differentiation

FIGURE 11-5 Role of CR2 and TLRs in B cell activation. In immune responses to microbes, activation of B cells through the BCR may be enhanced by complement-coated antigen that can simultaneously ligate the BCR and complement receptor 2 (CR2) (A), and may also involve the contemporaneous activation of Toll-like receptors (TLRs) on B cells by molecules (so-called pathogen-associated molecular patterns [PAMPs]) derived from the microbe (B).

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