Therapeutic Approaches For Immunologic Diseases

One of the most impressive accomplishments of immunology has been the development of novel therapies

Activated macrophage

Activated macrophage

Blood vessel

Lymphocyte

Macrophage

FIGURE 18-8 Granulomatous inflammation. A, Lymph node from a patient with tuberculosis containing granulomas with activated macrophages, multinucleate giant cells, and lymphocytes. In some granulomas, there may be a central area of necrosis. Immunohistochemical studies would identify the lymphocytes as T cells. B, Mechanisms of granuloma formation. Cytokines are involved in the generation of TH1 cells, activation of macrophages, and recruitment of leukocytes. Prolonged reactions of this type lead to the formation of granulomas.

Blood vessel

Lymphocyte

Macrophage

FIGURE 18-8 Granulomatous inflammation. A, Lymph node from a patient with tuberculosis containing granulomas with activated macrophages, multinucleate giant cells, and lymphocytes. In some granulomas, there may be a central area of necrosis. Immunohistochemical studies would identify the lymphocytes as T cells. B, Mechanisms of granuloma formation. Cytokines are involved in the generation of TH1 cells, activation of macrophages, and recruitment of leukocytes. Prolonged reactions of this type lead to the formation of granulomas.

based on the understanding of basic science and its application to human disease. The therapies can be divided into several broad groups.

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