Tcr

Extracellular space

FIGURE 7-8 Components of the TCR complex. The TCR complex of MHC-restricted T cells consists of the ap TCR noncovalently linked to the CD3 and Z proteins. The association of these proteins with one another is mediated by charged residues in their transmembrane regions, which are not shown.

Plasma membrane

Cytoplasm

Immunoreceptor □ tyrosine-based activation motif (ITAM)

Disulfide bond —

FIGURE 7-8 Components of the TCR complex. The TCR complex of MHC-restricted T cells consists of the ap TCR noncovalently linked to the CD3 and Z proteins. The association of these proteins with one another is mediated by charged residues in their transmembrane regions, which are not shown.

Receptors of CD4+ helper T lymphocyte

Ligands of class II MHC expressing APC

Signal transduction

Antigen recognition

Signal transduction

Adhesion

Peptide Class II MHC

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