* Disorders caused by abnormal immune responses are called hypersensitivity diseases. Pathologic immune responses may be autoimmune responses directed against self antigens or uncontrolled and excessive responses to foreign (e.g., microbial) antigens.

* Hypersensitivity diseases may result from antibodies that bind to cells or tissues, circulating immune complexes that are deposited in tissues, or T lymphocytes reactive with antigens in tissues.

* The effector mechanisms of antibody-mediated tissue injury are complement activation and Fc receptor-mediated inflammation. Some antibodies cause disease by interfering with normal cellular functions without producing tissue injury.

* The effector mechanisms of T cell-mediated tissue injury are inflammatory reactions induced by cytokines secreted mainly by CD4+ TH1 and TH17 cells and cell lysis by CTLs. The classical T cellmediated reaction is delayed-type hypersensitivity, induced by activation of previously primed T cells and the production of cytokines that recruit and activate various leukocytes, predominantly macrophages.

* The current treatment of autoimmune diseases is targeted at reducing immune activation and the injurious consequences of the autoimmune reaction. A future goal of therapy is to inhibit the

Was this article helpful?

0 0
How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment