Summary 315

Most of our discussion of innate and adaptive immunity so far in this book has covered features and mechanisms of immune responses in any anatomic location in the mammalian body. However, the immune system has evolved specialized properties in different parts of the body, especially at epithelial surfaces. These features are essential for protection against the types of microbial challenges that are most often encountered at these locations, and they also ensure tolerance to nonpathogenic commensal organisms that live on epithelia and in the lumens of mucosal organs (Table 13-1). The collection of components of the immune system serving specialized functions at a particular anatomic location is called a regional immune system. Most of this chapter is devoted to a discussion of these specialized immune systems. We end with a consideration of some tissues that do not normally support immune responses and are said to be immune privileged.

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