Recognition of Alloantigens

Recognition of transplanted cells as self or foreign is determined by polymorphic genes, called histocompatibility genes, which differ among different members of a species. This conclusion is based on the results of experimental transplantation between inbred strains of mice, and in some cases, the results have been confirmed in human transplantation. Remember that all the animals of an inbred strain are genetically identical, and they are homozygous for all genes (except the sex chromosomes in males). The basic rules of transplantation immunology, which are derived from such animal experiments, are the following (Fig. 16-3).

Donor (Strain A)

Skin graft

Graft rejection

Day 3-7 No

Graft rejection Day 10-14

Donor (Strain A)

Donor (Strain A)

Donor (Strain A)

Donor (Strain A)

Donor (Strain A)

Recipient (Strain B sensitized Recipient (Strain B injected by previous graft from strain with lymphocytes from another A donor) strain B animal that rejected a strain A graft)

Recipient (Strain B sensitized Recipient (Strain B injected by previous graft from strain with lymphocytes from another A donor) strain B animal that rejected a strain A graft)

Yes

Second set rejection I Second set rejection

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