Processing Of Protein Antigens

The pathways of antigen processing convert protein antigens present in the cytosol or internalized from the extracellular environment into peptides and load these peptides onto MHC molecules for display to T lymphocytes (Fig. 6-14). The mechanisms of antigen processing are designed to generate peptides that have the structural

Antigen uptake

Antigen processing

MHC biosynthesis

Peptide-MHC association

Peptides in cytosol^.

Peptides in cytosol^.

Class I

Cytosolic I MHC

protein Proteasome

Class I

Cytosolic I MHC

protein Proteasome

Endocytosis of extracellular protein

Invariant chain (Ii) Class II MHC

CD4+ T cell

Class II MHC pathway

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