If the recipient of an allograft has a fully functional immune system, transplantation almost invariably results in some form of rejection. The strategies used in clinical practice and in experimental models to avoid or to delay rejection are general immunosuppression and minimizing the strength of the specific allogeneic reaction. An important goal in transplantation research is to find ways of inducing donor-specific tolerance, which would allow grafts to survive without nonspecific immunosuppression.
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