Multiple activating receptors engaged

Inhibitory receptor

Self class I MHC-self peptide complex

Virus-infected cell (class I MHC negative)

Ineffective .. .. removal of Activating phosphates signals and inhibition

Ineffective .. .. removal of Activating phosphates signals and inhibition

Virus inhibits class I MHC expression

Virus-infected cell (class I MHC negative)

Stressed cell with induced expression of activating ligands

NK cell not activated; no cell killing

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