Migration Of Effector T Lymphocytes To Sites Of Infection

Some effector T cells exit the lymphoid organs where they were generated and preferentially home to sites of infection in peripheral tissues, where they are needed to eliminate microbes during the effector phase of adaptive immune responses (Fig. 10-3). In Chapter 3, we described naive T cell recirculation through lymphoid tissues and

Antigen recognition in lymphoid organs

T cell expansion and differentiation

CD8+

T cells (CTLs)

Differentiated effector T cells enter circulation

Migration of effector T cells and other leukocytes to site of antigen

Cells with intracellular microbes

Cytokines

Effector T cells encounter antigens in peripheral tissues

Activation of effector T cells

Effector functions of T cells

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