Intrinsic Mechanisms of Immune Evasion by Tumor Cells

Several properties of tumor cells enable them to escape host defenses.

• Tumors may lose expression of antigens that elicit immune responses. Such "antigen loss variants" are c <

Tumor

Tumor

Tumor mhc antigen molecule

T cell specific for tumor antigen

T cell recognition of tumor antigen leading to T cell activation

Failure to produce tumor antigen

Antigen-loss variant of tumor cell

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