Info

Naive Cell

Activated or Effector Lymphocytes

Memory Lymphocytes

T Lymphocytes

Migration

Preferentially to peripheral lymph nodes

Preferentially to inflamed tissues

Preferentially to inflamed tissues, mucosal tissues

Frequency of cells responsive to particular antigen

Very low

High

Low

Effector functions

None

Cytokine secretion; cytotoxic activity

None

Cell cycling

No

Yes

+/-

Surface protein expression IL-2R (CD25) L-selectin (CD62L) IL-7R (CD127)

Adhesion molecules: integrins, CD44 Chemokine receptor: CCR7 Major CD45 isoform (humans only)

Low High

Moderately high

High

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