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Cytokines produced on activation

IL-3, IL-5, GM-CSF IL-8, IL-10, RANTES, MIP-1a, eotaxin

Eosinophil production and activation Chemotaxis of leukocytes

GM-CSF, granulocyte-monocyte colony-stimulating factor; IL, interleukin, MIP-1a, monocyte inflammatory protein 1a; RANTES, regulated by activation, normal T cell expressed and secreted; TNF, tumor necrosis factor.

The function of the receptor on many of these cells is not established.

Each FceRI molecule is composed of an a chain that binds the Fc region of IgE and a p chain and two y chains that are responsible for signaling (Fig. 19-3). The amino-terminal extracellular portion of the a chain includes two Ig-like domains that form the binding site for IgE. The

P chain of FceRI contains a single immunoreceptor tyrosine-based activation motif (ITAM) in the cytoplasmic carboxyl terminal domain. The two identical y chain polypeptides are linked by a disulfide bond and are homologous to the Z chain of the T cell antigen receptor complex (see Chapter 7). The cytoplasmic portion of each y chain contains one ITAM. The same y chain serves as

TABLE 19-3 Mast Cell Subsets

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