The potential number of antigen receptors with junctional diversity is much greater than the number that can be generated only by combinations of V, D, and J gene segments. Note that although the upper limit on the numbers of Ig and TCR proteins that may be expressed is very large, it is estimated that each individual contains on the order of 107 clones of B and T cells with distinct specificities and receptors; in other words, only a fraction of the potential repertoire may actually be expressed.



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