Info

Class

Functions

Blood

Lymph Node

Spleen

aP T lymphocytes CD4+ helper T lymphocytes

CD8+ cytotoxic T lymphocytes

Regulatory T cells yS T lymphocytes

B cell differentiation (humoral immunity) Macrophage activation

(cell-mediated immunity) Stimulation of inflammation Killing of cells infected with viruses or intracellular bacteria; rejection of allografts Suppress function of other T cells (regulation of immune responses, maintenance of self-tolerance) Helper and cytotoxic functions (innate immunity)

aP heterodimers Diverse specificities for peptide-class II MHC complexes aP heterodimers Diverse specificities for peptide-class I MHC complexes aP heterodimers Unresolved yS heterodimers Limited specificities for peptide and nonpeptide antigens

CD3+, CD4+, CD25+ (most common, but other phenotypes as well) CD3+, CD4+, and CD8 variable

20-25 Rare

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