aP T lymphocytes CD4+ helper T lymphocytes
CD8+ cytotoxic T lymphocytes
Regulatory T cells yS T lymphocytes
B cell differentiation (humoral immunity) Macrophage activation
(cell-mediated immunity) Stimulation of inflammation Killing of cells infected with viruses or intracellular bacteria; rejection of allografts Suppress function of other T cells (regulation of immune responses, maintenance of self-tolerance) Helper and cytotoxic functions (innate immunity)
aP heterodimers Diverse specificities for peptide-class II MHC complexes aP heterodimers Diverse specificities for peptide-class I MHC complexes aP heterodimers Unresolved yS heterodimers Limited specificities for peptide and nonpeptide antigens
CD3+, CD4+, CD25+ (most common, but other phenotypes as well) CD3+, CD4+, and CD8 variable
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