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The Peripheral Neuropathy Solution

The Peripheral Neuropathy Solution

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Candida albicans

Candidiasis

Unknown; binds complement proteins

Aspergillus fumigatus

Aspergillosis

Invasion and thrombosis of blood vessels causing ischemic necrosis and cell injury

Histoplasma capsulatum

Histoplasmosis

Lung infection caused by granulomatous inflammation

Viruses

Polio

Poliomyelitis

Inhibits host cell protein synthesis (tropism for motor neurons in the anterior horn of the spinal cord)

Influenza

Influenza pneumonia

Inhibits host cell protein synthesis (tropism for peripheral nerves)

Rabies

Rabies encephalitis

Inhibits host cell protein synthesis (tropism for ciliated peripheral nerves)

Herpes simplex

Various herpes infections (skin, systemic)

Inhibits host cell protein synthesis; functional impairment of immune cells

Hepatitis B

Viral hepatitis

Host CTL response to infected hepatocytes

Epstein-Barr virus

Infectious mononucleosis; B cell proliferation, lymphomas

Acute infection: cell lysis (tropism for B lymphocytes) Latent infection: stimulates B cell proliferation

Human immunodeficiency virus (HIV)

Acquired immunodeficiency syndrome (AIDS)

Multiple: killing of CD4+ T cells, functional impairment of immune cells (see Chapter 20)

Examples of pathogenic microbes of different classes are listed, with brief summaries of known or postulated mechanisms of tissue injury and disease. Examples of parasites are listed in Table 15-4. ADP, adenosine diphosphate; AMP, adenosine monophosphate; CTL, cytotoxic T lymphocyte; LPS, lipopolysaccharide. This table was compiled with the assistance of Dr. Arlene Sharpe, Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

into sites of infection (inflammation). The recruited leukocytes ingest and destroy the bacteria.

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