Unknown; binds complement proteins
Invasion and thrombosis of blood vessels causing ischemic necrosis and cell injury
Lung infection caused by granulomatous inflammation
Inhibits host cell protein synthesis (tropism for motor neurons in the anterior horn of the spinal cord)
Inhibits host cell protein synthesis (tropism for peripheral nerves)
Inhibits host cell protein synthesis (tropism for ciliated peripheral nerves)
Various herpes infections (skin, systemic)
Inhibits host cell protein synthesis; functional impairment of immune cells
Host CTL response to infected hepatocytes
Infectious mononucleosis; B cell proliferation, lymphomas
Acute infection: cell lysis (tropism for B lymphocytes) Latent infection: stimulates B cell proliferation
Human immunodeficiency virus (HIV)
Acquired immunodeficiency syndrome (AIDS)
Multiple: killing of CD4+ T cells, functional impairment of immune cells (see Chapter 20)
Examples of pathogenic microbes of different classes are listed, with brief summaries of known or postulated mechanisms of tissue injury and disease. Examples of parasites are listed in Table 15-4. ADP, adenosine diphosphate; AMP, adenosine monophosphate; CTL, cytotoxic T lymphocyte; LPS, lipopolysaccharide. This table was compiled with the assistance of Dr. Arlene Sharpe, Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
into sites of infection (inflammation). The recruited leukocytes ingest and destroy the bacteria.
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