Activation |

Costimulatory blockade

FIGURE 9-7 The mechanism of therapeutic costimulatory blockade. A fusion protein of the extracellular portion of CTLA-4 and the Fc tail of an IgG molecule is used to bind to and block B7 molecules, thus preventing their interaction with the activating receptor CD28 and inhibiting T cell activation.

remainder of this chapter, we will describe each of these steps, their underlying mechanisms, and their functional consequences.

Was this article helpful?

0 0
How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment