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Costimulatory blockade

FIGURE 9-7 The mechanism of therapeutic costimulatory blockade. A fusion protein of the extracellular portion of CTLA-4 and the Fc tail of an IgG molecule is used to bind to and block B7 molecules, thus preventing their interaction with the activating receptor CD28 and inhibiting T cell activation.

remainder of this chapter, we will describe each of these steps, their underlying mechanisms, and their functional consequences.

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