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Associates with collectins or ficolins and MASP1 and cleaves C4

*Published concentrations may have been influenced by cross-reactivity of antibodies with MASP3; concentrations of the latter are derived by use of specific monoclonal antibodies.

C6 and C7 bind sequentially, and the C5b,6,7 complex becomes directly inserted into the lipid bilayer of the plasma membrane, followed by stable insertion of C8. Up to 15 C9 molecules may then polymerize around the complex to form the MAC, which creates pores in the membrane and induces cell lysis. C5a released on proteolysis of C5 stimulates inflammation.

C6 and C7 bind sequentially, and the C5b,6,7 complex becomes directly inserted into the lipid bilayer of the plasma membrane, followed by stable insertion of C8. Up to 15 C9 molecules may then polymerize around the complex to form the MAC, which creates pores in the membrane and induces cell lysis. C5a released on proteolysis of C5 stimulates inflammation.

TABLE 12-7 Proteins of the Late Steps of Complement Activation

Protein

Structure

Serum Concentration

(|xg/mL)

Function

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