Il5

Inhibits eosinophil activation

Asthma

The table lists examples of antagonists against cytokines (antibodies or soluble receptors) that are approved for clinical use or in trials. IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.

to shut off specific immune responses. A risk of many treatments that block various components of the immune system is that these will interfere with the normal function of the immune system in combating microbes and thus make individuals susceptible to infections. Antigen-specific tolerance avoids this problem by selectively targeting the disease-causing lymphocytes. These general principles are similar to those on which treatment of transplant rejection is based (see Chapter 16).

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