Goe

Costimulator (e.g., B7) CD28

Response

Effector T cells

B cell

Effector T cell

Effector T cell

Antibody

FIGURE 6-2 Functions of different antigen-presenting cells. The three major types of APCs for CD4+ T cells function to display antigens at different stages and in different types of immune responses. Note that effector T cells activate macrophages and B lymphocytes by production of cytokines and by expressing surface molecules; these will be described in later chapters.

Antibody

Naive T cell activation: clonal expansion and differentiation into effector T cells

Macrophage

Effector

V, Killed

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