HIV Reservoirs and Viral Turnover

The virus detected in patients' blood is produced mostly by short-lived infected CD4+ T cells and in smaller amounts by other infected cells. Three phases of decay of plasma viremia have been observed in patients treated with anti-retroviral drugs or predicted by mathematical modeling, and these decay curves have been used to surmise the distribution of HIV in different cellular reservoirs. More than 90% of plasma virus is believed to be produced by short-lived cells (half-lives of ~1 day), which are most likely activated CD4+ T cells that are major reservoirs and sources of the virus in infected patients. About 5% of plasma virus is produced by macrophages, which have a slower turnover (half-life of about 2 weeks). It is hypothesized that a small fraction of the virus, perhaps as little as 1%, is present in latently infected memory T cells. Because of the long life span of memory cells, it could take decades for this reservoir of virus to be eliminated even if all new rounds of infection were blocked.

Was this article helpful?

0 0
How To Win Your War Against Allergies

How To Win Your War Against Allergies

Not Able To Lead A Happy Life Because Of Excessive Allergies? Want To Badly Get Rid Of Your Allergy Problems, But Are Super Confused And Not Sure Where To Even Start? Don't Worry, Help Is Just Around The Corner Revealed The All-In-One Power Packed Manual Containing Ample Strategies And Little-Known Tips To Get Rid Of Any Allergy Problems That Are Ruining Your Life Learn How You Can Eliminate Allergies Completely Reclaim Your Life Once Again

Get My Free Ebook

Post a comment