Graft VersusLeukemia Effect

In leukemia patients, administration of alloreactive T cells together with hematopoietic stem cell transplants can contribute to eradication of the tumor. This graft-versus-leukemia effect is directed at the allogeneic MHC molecules present on the recipient's hematopoietic cells, including the leukemia cells. The challenge in use of this treatment to improve clinical outcome is to minimize the dangerous graft-versus-host disease that may be mediated by the same donor T cells (see Chapter 16).

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