• Tumors stimulate specific, adaptive immune responses.
Clinical observations and animal experiments have established that although tumor cells are derived from host cells, the tumors elicit immune responses. Histo-pathologic studies show that many tumors are surrounded by mononuclear cell infiltrates composed of T lymphocytes, natural killer (NK) cells, and macrophages, and that activated lymphocytes and macrophages are present in lymph nodes draining the sites of tumor growth (Fig. 17-1). The presence of
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