General Features Of Tumor Immunity

Several characteristics of tumor antigens and immune responses to tumors are fundamental to an understanding of tumor immunity and for the development of strategies for cancer immunotherapy.

• Tumors stimulate specific, adaptive immune responses.

Clinical observations and animal experiments have established that although tumor cells are derived from host cells, the tumors elicit immune responses. Histo-pathologic studies show that many tumors are surrounded by mononuclear cell infiltrates composed of T lymphocytes, natural killer (NK) cells, and macrophages, and that activated lymphocytes and macrophages are present in lymph nodes draining the sites of tumor growth (Fig. 17-1). The presence of

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