Functions of TH17 Cells

Th17 cells secrete cytokines that recruit leukocytes, mainly neutrophils, to sites of infection (Fig. 10-10). Because neutrophils are a major defense mechanism against extracellular bacteria and fungi, TH17 cells play an especially important role in defense against these infections.

Cytokines Produced by TH17 Cells

Th17 cells produce several cytokines. Most of the inflammatory actions of these cells are mediated by IL-17, but other cytokines produced by this subset may also contribute.

Bacteria

Bacteria

Naive CD4+ T cell

Naive CD4+ T cell

Proliferation and differentiation

Th17 cells

Leukocytes and tissue cells y V

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