Effector Functions Of Cd8 Cytotoxic T Lymphocytes

CD8+ CTLs eliminate intracellular microbes mainly by killing infected cells (see Fig. 10-1B). The development of a CD8+ CTL response to infection proceeds through similar steps as those described for CD4+ T cell responses, including antigen-mediated stimulation of naive CD8+ T cells in lymphoid organs, clonal expansion, differentiation, and migration of differentiated CTLs into tissues. These events were described in Chapter 9. In addition to direct cell killing, CD8+ T cells secrete IFN-y and thus contribute to macrophage activation in host defense and in hypersensitivity reactions. Here we discuss the mechanisms by which differentiated CTLs kill cells harboring microbes.

Was this article helpful?

0 0
How To Win Your War Against Allergies

How To Win Your War Against Allergies

Not Able To Lead A Happy Life Because Of Excessive Allergies? Want To Badly Get Rid Of Your Allergy Problems, But Are Super Confused And Not Sure Where To Even Start? Don't Worry, Help Is Just Around The Corner Revealed The All-In-One Power Packed Manual Containing Ample Strategies And Little-Known Tips To Get Rid Of Any Allergy Problems That Are Ruining Your Life Learn How You Can Eliminate Allergies Completely Reclaim Your Life Once Again

Get My Free Ebook


Post a comment