Effector Functions of Alloreactive T Cells

Alloreactive CD4+ and CD8+ T cells that are activated by graft alloantigens cause rejection by distinct mechanisms.

The CD4+ helper T cells differentiate into cytokine-producing effector cells that damage grafts by cytokine-mediated inflammation, similar to a delayed-type immune responses to allografts 373

Mix blood mononuclear cells from two donors in tissue culture

Responder T cell recognition of allogeneic MHC molecules

Clonal expansion and functional differentiation of responder T cells

Effector functions of T cells

Donor Y

Primary MLR

Donor X CD8| T lymphocyte (Responder cell)

Donor X activated CD8| CTLs

Class I MHC

Class II MHC

Class I MHC

Class II MHC

Donor X CD8| T lymphocyte (Responder cell)

Donor Y APC (Stimulator cell)

Donor Y APC (Stimulator cell)

Donor X activated CD8| CTLs

Donor Y class I MHC| target cell

Donor X CD4+ T lymphocyte (Responder cell)

Donor X activated CD4+ helper T cells

Donor Y class I MHC| target cell

', Donor Y class II \ MHC+ stimulator cell

Lysis of target cell

', Donor Y class II \ MHC+ stimulator cell

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